INDUCE-seq Results

EMX1_Cas9_4h

Nominations

Chr Start End Count Rationale Guide name Reproducibility Count (EMX1 cas9 4h rep1) Count (EMX1 cas9 4h rep2) Count (EMX1 cas9 4h rep3) EMX1 Cas9 mismatches Intersect with genes Intersect with repeat mask Width Plus count Minus count Count ratio Normalised sample to control ratio Percent id to EMX1 Cas9 Break site probability scores
chr2 72933868 72933870 95 frequency-based,homology-based EMX1_Cas9 3/3 33 42 20 0 EMX1,ENSG00000278060 2 57 38 1.50 100.0 100.00
chr5 45358964 45358965 20 frequency-based,homology-based EMX1_Cas9 3/3 3 15 2 2 HCN1 LTR49 1 7 13 1.86 91.3 100.00
chr14 75489025 75489028 6 frequency-based 2/3 3 3 0 3 4 2 2.00 5.00 56.52 100.00
chr15 43817564 43817565 3 homology-based EMX1_Cas9 3/3 1 1 1 3 MFAP1 1 3 0 86.96 0.00
chr3 19205780 19205782 2 homology-based EMX1_Cas9 2/3 1 0 1 6 KCNH8 L2c,L1PB1 2 0 2 73.91 0.00
chr5 9227049 9227050 2 homology-based EMX1_Cas9 2/3 0 1 1 3 SEMA5A (AT)n 1 1 1 1.00 86.96 0.00
chr8 127789011 127789012 2 homology-based EMX1_Cas9 1/3 0 2 0 3 1 2 0 86.96 0.00
chr11 118924225 118924226 2 homology-based EMX1_Cas9 2/3 0 1 1 6 BCL9L 1 2 0 73.91 0.00
chr15 92337937 92337938 2 homology-based EMX1_Cas9 2/3 1 1 0 6 MLT1D 1 2 0 73.91 0.00
chr7 122955941 122955942 1 homology-based EMX1_Cas9 1/3 0 1 0 4 MLT1E2 1 0 1 82.61 0.00
chr22 39802994 39802995 1 homology-based EMX1_Cas9 1/3 0 1 0 4 ENTHD1 L2a 1 0 1 82.61 0.00

Breaksite Plots

Mismatch Plots

EMX1_Cas9_4h EMX1_Cas9

EMX1_Cas9_8h

Nominations

Chr Start End Count Rationale Guide name Reproducibility Count (EMX1 cas9 8h rep1) Count (EMX1 cas9 8h rep2) Count (EMX1 cas9 8h rep3) EMX1 Cas9 mismatches Intersect with genes Intersect with repeat mask Width Plus count Minus count Count ratio Normalised sample to control ratio Percent id to EMX1 Cas9 Break site probability scores
chr2 72933868 72933869 44 frequency-based,homology-based EMX1_Cas9 3/3 16 18 10 0 EMX1,ENSG00000278060 1 31 13 2.38 100.0 100.00
chr5 45358963 45358965 18 frequency-based,homology-based EMX1_Cas9 3/3 10 4 4 2 HCN1 LTR49 2 5 13 2.60 91.3 100.00
chr8 140636262 140636265 7 frequency-based 3/3 3 2 2 ERICD 3 3 4 1.33 43.48 96.88
chr2 189412614 189412617 6 frequency-based 3/3 3 1 2 3 5 1 5.00 56.52 87.98
chr8 100827229 100827231 6 frequency-based 3/3 1 4 1 2 6 0 3.47 47.83 87.98
chr9 36407284 36407285 6 frequency-based 3/3 2 3 1 RNF38 1 6 0 47.83 87.98
chr15 80970257 80970260 6 frequency-based 2/3 0 1 5 MESD 3 3 3 1.00 47.83 87.98
chr20 34303452 34303454 6 frequency-based 3/3 4 1 1 AHCY 2 1 5 5.00 52.17 87.98
chr1 87648196 87648199 5 frequency-based 3/3 2 1 2 PKN2-AS1 MIRc 3 2 3 1.50 52.17 53.36
chr2 196066941 196066945 5 frequency-based 3/3 2 1 2 DNAH7 4 1 4 4.00 43.48 53.36
chr5 132489598 132489601 5 frequency-based 2/3 0 2 3 ENSG00000283782,IRF1 3 4 1 4.00 47.83 53.36
chr5 143435472 143435476 5 frequency-based 2/3 3 0 2 NR3C1 GA-rich 4 4 1 4.00 65.22 53.36
chr12 3873554 3873557 5 frequency-based 3/3 2 2 1 PARP11-AS1 3 1 4 4.00 66.67 53.36
chr12 105053198 105053200 5 frequency-based 2/3 3 2 0 NOPCHAP1,ALDH1L2 2 1 4 4.00 43.48 53.36
chr15 43817564 43817565 5 frequency-based,homology-based EMX1_Cas9 3/3 1 2 2 3 MFAP1 1 4 1 4.00 86.96 53.36
chr17 2401044 2401046 5 frequency-based 2/3 2 3 0 MNT (CTCC)n 2 2 3 1.50 69.57 53.36
chr17 38322332 38322335 5 frequency-based 2/3 3 2 0 MRPL45 3 1 4 4.00 56.52 53.36
chr17 58659569 58659572 5 frequency-based 2/3 0 3 2 TEX14 3 2 3 1.50 56.52 53.36
chr5 9227049 9227051 3 homology-based EMX1_Cas9 2/3 0 2 1 3 SEMA5A (AT)n 2 3 0 86.96 0.15
chr6 9118565 9118566 2 homology-based EMX1_Cas9 2/3 0 1 1 3 HULC 1 1 1 1.00 86.96 0.00
chr11 86447260 86447262 2 homology-based EMX1_Cas9 2/3 1 0 1 6 ENSG00000254733,ME3 2 1 1 1.00 73.91 0.00
chr8 127789011 127789012 1 homology-based EMX1_Cas9 1/3 1 0 0 3 1 0 1 86.96 0.00
chr17 46192774 46192775 1 homology-based EMX1_Cas9 1/3 0 0 1 4 KANSL1 (GAGCAG)n 1 0 1 82.61 0.00

Breaksite Plots

Mismatch Plots

EMX1_Cas9_8h EMX1_Cas9

HPRT1_Cas12a_4h

Nominations

Chr Start End Count Rationale Guide name Reproducibility Count (HPRT1 cas12a 4h rep1) Count (HPRT1 cas12a 4h rep2) Count (HPRT1 cas12a 4h rep3) HPRT1 Cas12a mismatches Intersect with genes Intersect with repeat mask Width Plus count Minus count Count ratio Normalised sample to control ratio Percent id to HPRT1 Cas12a Break site probability scores
chrX 134498435 134498481 254 frequency-based,homology-based HPRT1_Cas12a 3/3 87 86 81 0 HPRT1 46 143 111 1.29 100.0 100.00
chr1 145996844 145996853 6 frequency-based 3/3 2 2 2 GA-rich 9 2 4 2.00 48.0 0.00
chr3 13648379 13648386 6 frequency-based 3/3 3 1 2 7 3 3 1.00 44.0 0.00
chr16 30628965 30628977 6 frequency-based 3/3 3 2 1 MIRb 12 1 5 5.00 48.0 0.00
chr17 50372936 50372944 6 frequency-based 3/3 2 1 3 MRPL27 8 5 1 5.00 40.0 0.00

Breaksite Plots

Mismatch Plots

HPRT1_Cas12a_4h HPRT1_Cas12a

HPRT1_Cas12a_8h

Nominations

Chr Start End Count Rationale Guide name Reproducibility Count (HPRT1 cas12a 8h rep1) Count (HPRT1 cas12a 8h rep2) Count (HPRT1 cas12a 8h rep3) HPRT1 Cas12a mismatches Intersect with genes Intersect with repeat mask Width Plus count Minus count Count ratio Normalised sample to control ratio Percent id to HPRT1 Cas12a Break site probability scores
chrX 134498436 134498483 89 frequency-based,homology-based HPRT1_Cas12a 3/3 24 35 30 0 HPRT1 47 53 36 1.47 100.0 100.00
chr6 41368968 41368978 5 frequency-based 2/3 3 2 0 MIRb 10 3 2 1.50 40.0 0.00
chr6 43722383 43722394 5 frequency-based 2/3 3 0 2 MLT1N2 11 3 2 1.50 44.0 0.00
chr6 71080352 71080359 5 frequency-based 2/3 2 0 3 MIRc,MIR 7 2 3 1.50 44.0 0.00
chr10 67116230 67116238 5 frequency-based 2/3 0 2 3 CTNNA3 8 0 5 52.0 0.00
chr17 60638967 60638969 5 frequency-based 3/3 2 2 1 PPM1D L2c 2 5 0 52.0 0.00
chr22 37817751 37817755 5 frequency-based 2/3 1 4 0 4 2 3 1.50 52.0 0.00
chrX 40945537 40945540 5 frequency-based 2/3 0 1 4 3 3 2 1.50 40.0 0.00

Breaksite Plots

Mismatch Plots

HPRT1_Cas12a_8h HPRT1_Cas12a

HPRT1_Custom_4h

Nominations

Chr Start End Count Rationale Guide name Reproducibility Count (HPRT1 custom 4h rep1) Count (HPRT1 custom 4h rep2) Count (HPRT1 custom 4h rep3) HPRT1 Custom mismatches Intersect with genes Intersect with repeat mask Width Plus count Minus count Count ratio Normalised sample to control ratio Percent id to HPRT1 Custom Break site probability scores
chrX 134498435 134498481 254 frequency-based,homology-based HPRT1_Custom 3/3 87 86 81 0 HPRT1 46 143 111 1.29 100.0 100.00
chr1 145996828 145996853 8 frequency-based 3/3 3 2 3 GA-rich 25 2 6 3.00 48.0 0.00
chr1 66726208 66726223 6 frequency-based 2/3 0 5 1 SGIP1 LTR41 15 4 2 2.00 48.0 0.00
chr1 225446100 225446118 6 frequency-based 2/3 0 1 5 18 3 3 1.00 44.0 0.00
chr3 13648379 13648386 6 frequency-based 3/3 3 1 2 7 3 3 1.00 44.0 0.00
chr6 114096701 114096719 6 frequency-based 3/3 3 2 1 HDAC2-AS2,HS3ST5 18 4 2 2.00 52.0 0.00
chr16 30628965 30628977 6 frequency-based 3/3 3 2 1 MIRb 12 1 5 5.00 48.0 0.00
chr17 50372936 50372944 6 frequency-based 3/3 2 1 3 MRPL27 8 5 1 5.00 40.0 0.00
chr19 55166589 55166606 6 frequency-based 2/3 0 4 2 DNAAF3,DNAAF3-AS1 17 6 0 44.0 0.00
chr19 57104192 57104215 6 frequency-based 2/3 0 4 2 (GTTTT)n 23 3 3 1.00 44.0 0.00
chrX 101626295 101626296 1 homology-based HPRT1_Custom 1/3 0 1 0 3 ARMCX3 1 0 1 88.0 0.00

Breaksite Plots

Mismatch Plots

HPRT1_Custom_4h HPRT1_Custom

HPRT1_Custom_Discovery_4h

Nominations

Chr Start End Count Rationale Guide name Reproducibility Count (HPRT1 custom discovery 4h rep1) Count (HPRT1 custom discovery 4h rep2) Count (HPRT1 custom discovery 4h rep3) HPRT1 Custom Discovery mismatches Intersect with genes Intersect with repeat mask Width Plus count Minus count Count ratio Normalised sample to control ratio Percent id to HPRT1 Custom Discovery Break site probability scores
chrX 134498448 134498472 244 frequency-based,homology-based HPRT1_Custom_Discovery 3/3 86 79 79 0 HPRT1 24 139 105 1.32 100.0 100.00
chrX 134498476 134498481 4 homology-based HPRT1_Custom_Discovery 3/3 1 1 2 0 HPRT1 5 4 0 100.0 0.00
chr2 195544747 195544748 2 homology-based HPRT1_Custom_Discovery 1/3 0 2 0 6 1 2 0 76.0 0.00
chr2 223047127 223047128 2 homology-based HPRT1_Custom_Discovery 1/3 0 0 2 6 MIR 1 0 2 76.0 0.00
chr6 72239707 72239708 2 homology-based HPRT1_Custom_Discovery 1/3 0 0 2 5 RIMS1 1 0 2 72.0 0.00
chr11 92935593 92935595 2 homology-based HPRT1_Custom_Discovery 2/3 1 0 1 6 LTR64 2 0 2 76.0 0.00
chr12 102994516 102994517 2 homology-based HPRT1_Custom_Discovery 2/3 1 1 0 6 L1ME1 1 2 0 76.0 0.00
chr14 49151782 49151784 2 homology-based HPRT1_Custom_Discovery 2/3 1 0 1 6 L2c 2 0 2 76.0 0.00
chr19 54194456 54194457 2 homology-based HPRT1_Custom_Discovery 2/3 1 1 0 6 TSEN34 1 2 0 76.0 0.00
chr1 61121179 61121180 1 homology-based HPRT1_Custom_Discovery 1/3 0 1 0 6 NFIA 1 1 0 76.0 0.00
chr1 61121184 61121185 1 homology-based HPRT1_Custom_Discovery 1/3 0 0 1 6 NFIA 1 0 1 76.0 0.00
chr1 223652426 223652427 1 homology-based HPRT1_Custom_Discovery 1/3 0 0 1 6 CAPN8 1 0 1 48.0 0.00
chr1 223652439 223652440 1 homology-based HPRT1_Custom_Discovery 1/3 1 0 0 6 CAPN8 1 0 1 76.0 0.00
chr2 172593448 172593449 1 homology-based HPRT1_Custom_Discovery 1/3 0 0 1 6 PDK1 Tigger13a 1 0 1 48.0 0.00
chr2 172593454 172593455 1 homology-based HPRT1_Custom_Discovery 1/3 1 0 0 6 PDK1 Tigger13a 1 0 1 76.0 0.00
chr2 172593467 172593468 1 homology-based HPRT1_Custom_Discovery 1/3 1 0 0 6 PDK1 Tigger13a 1 1 0 76.0 0.00
chr2 195544738 195544739 1 homology-based HPRT1_Custom_Discovery 1/3 0 0 1 6 1 0 1 76.0 0.00
chr4 79881638 79881639 1 homology-based HPRT1_Custom_Discovery 1/3 0 0 1 6 1 0 1 76.0 0.00
chr4 79881644 79881645 1 homology-based HPRT1_Custom_Discovery 1/3 1 0 0 6 1 1 0 76.0 0.00
chr4 102023956 102023957 1 homology-based HPRT1_Custom_Discovery 1/3 0 0 1 6 BANK1,ENSG00000251309 1 0 1 76.0 0.00
chr4 102023962 102023963 1 homology-based HPRT1_Custom_Discovery 1/3 0 1 0 6 BANK1,ENSG00000251309 1 0 1 52.0 0.00
chr5 83068851 83068852 1 homology-based HPRT1_Custom_Discovery 1/3 1 0 0 6 TMEM167A 1 0 1 76.0 0.00
chr5 83068857 83068858 1 homology-based HPRT1_Custom_Discovery 1/3 0 1 0 6 TMEM167A 1 1 0 76.0 0.00
chr6 36339099 36339100 1 homology-based HPRT1_Custom_Discovery 1/3 1 0 0 6 L1MB3 1 0 1 76.0 0.00
chr6 36339105 36339106 1 homology-based HPRT1_Custom_Discovery 1/3 0 1 0 6 L1MB3 1 1 0 76.0 0.00
chr6 72239704 72239705 1 homology-based HPRT1_Custom_Discovery 1/3 1 0 0 5 RIMS1 1 0 1 80.0 0.00
chr7 108318430 108318431 1 homology-based HPRT1_Custom_Discovery 1/3 0 0 1 5 NRCAM MER5A 1 0 1 60.0 0.00
chr7 108318462 108318463 1 homology-based HPRT1_Custom_Discovery 1/3 1 0 0 5 NRCAM MER5A 1 0 1 56.0 0.00
chr9 28923189 28923190 1 homology-based HPRT1_Custom_Discovery 1/3 0 0 1 4 LINGO2 MLT1D 1 0 1 84.0 0.00
chr11 15195040 15195041 1 homology-based HPRT1_Custom_Discovery 1/3 1 0 0 6 INSC MER5B 1 0 1 76.0 0.00
chr11 15195052 15195053 1 homology-based HPRT1_Custom_Discovery 1/3 1 0 0 6 INSC MER5B 1 1 0 76.0 0.00
chr11 90449334 90449335 1 homology-based HPRT1_Custom_Discovery 1/3 0 1 0 6 DISC1FP1 1 0 1 76.0 0.00
chr11 90449338 90449339 1 homology-based HPRT1_Custom_Discovery 1/3 0 1 0 6 DISC1FP1 1 0 1 72.0 0.00
chr13 38230704 38230705 1 homology-based HPRT1_Custom_Discovery 1/3 1 0 0 6 LINC00571 L1PA11 1 0 1 76.0 0.00
chr13 38230707 38230708 1 homology-based HPRT1_Custom_Discovery 1/3 0 1 0 6 LINC00571 L1PA11 1 1 0 76.0 0.00
chr17 61104009 61104010 1 homology-based HPRT1_Custom_Discovery 1/3 0 1 0 6 BCAS3 1 0 1 76.0 0.00
chr17 61104017 61104018 1 homology-based HPRT1_Custom_Discovery 1/3 0 1 0 6 BCAS3 1 1 0 76.0 0.00
chr18 5207757 5207758 1 homology-based HPRT1_Custom_Discovery 1/3 0 0 1 6 ENSG00000285575 1 1 0 76.0 0.00
chr18 5207775 5207776 1 homology-based HPRT1_Custom_Discovery 1/3 0 0 1 6 ENSG00000285575 1 1 0 76.0 0.00
chr21 21736153 21736154 1 homology-based HPRT1_Custom_Discovery 1/3 0 0 1 4 LINC00317 1 0 1 84.0 0.00
chrX 101626295 101626296 1 homology-based HPRT1_Custom_Discovery 1/3 0 1 0 3 ARMCX3 1 0 1 88.0 0.00

Breaksite Plots

Mismatch Plots

HPRT1_Custom_Discovery_4h HPRT1_Custom_Discovery

asisi_treated

Nominations

Chr Start End Count Rationale Guide name Reproducibility Count (asisi digested rep1) Count (asisi digested rep2) Count (asisi digested rep3) Asisi mismatches Intersect with genes Intersect with repeat mask Width Plus count Minus count Count ratio Percent id to asisi
chr17 82292965 82292972 125 frequency-based,homology-based asisi 3/3 53 32 40 0 MLT1K 7 42 83 1.98 100.0
chr17 59106936 59106940 124 frequency-based,homology-based asisi 3/3 40 34 50 0 TRIM37,ENSG00000224738 G-rich 4 60 64 1.07 100.0
chr1 88992914 88992920 116 frequency-based,homology-based asisi 3/3 36 43 37 0 KYAT3,RBMXL1 6 61 55 1.11 100.0
chr2 68157617 68157622 104 frequency-based,homology-based asisi 3/3 29 41 34 0 ENSG00000273398 5 55 49 1.12 100.0
chr9 127930892 127930896 80 frequency-based,homology-based asisi 3/3 29 30 21 0 4 37 43 1.16 100.0
chr20 43458478 43458482 78 frequency-based,homology-based asisi 3/3 33 29 16 0 SRSF6,ENSG00000288000 4 36 42 1.17 100.0
chr22 38468096 38468101 75 frequency-based,homology-based asisi 3/3 29 27 19 0 KDELR3 5 36 39 1.08 100.0
chr20 32358509 32358514 74 frequency-based,homology-based asisi 3/3 20 27 27 0 ASXL1 (GCC)n 5 19 55 2.89 100.0
chr1 40508972 40508976 69 frequency-based,homology-based asisi 3/3 22 22 25 0 EXO5 4 37 32 1.16 100.0
chr18 7566715 7566719 68 frequency-based,homology-based asisi 3/3 13 24 31 0 4 19 49 2.58 100.0
chr18 21740841 21740848 68 frequency-based,homology-based asisi 3/3 23 17 28 0 MIB1 7 31 37 1.19 100.0
chr1 109494078 109494082 67 frequency-based,homology-based asisi 3/3 22 30 15 0 CYB561D1 4 40 27 1.48 100.0
chr3 99818120 99818126 67 frequency-based,homology-based asisi 3/3 25 22 20 0 CMSS1 6 36 31 1.16 100.0
chr6 31137651 31137655 60 frequency-based,homology-based asisi 3/3 15 18 27 0 PSORS1C1,PSORS1C2 4 32 28 1.14 100.0
chr17 21042988 21042992 59 frequency-based,homology-based asisi 3/3 21 22 16 0 USP22 4 32 27 1.19 100.0
chr1 19485661 19485665 58 frequency-based,homology-based asisi 3/3 19 24 15 0 MICOS10 (GCGGC)n 4 34 24 1.42 100.0
chr2 119366990 119366994 57 frequency-based,homology-based asisi 3/3 21 16 20 0 DBI 4 34 23 1.48 100.0
chr6 89638468 89638472 56 frequency-based,homology-based asisi 3/3 14 20 22 0 LYRM2 4 27 29 1.07 100.0
chr17 63773496 63773500 56 frequency-based,homology-based asisi 3/3 19 12 25 0 CCDC47 4 34 22 1.55 100.0
chr19 45428822 45428826 54 frequency-based,homology-based asisi 3/3 16 17 21 0 ERCC1 4 28 26 1.08 100.0
chr7 4682499 4682503 53 frequency-based,homology-based asisi 3/3 19 20 14 0 FOXK1 4 21 32 1.52 100.0
chr5 143405485 143405489 52 frequency-based,homology-based asisi 3/3 18 11 23 0 NR3C1 4 16 36 2.25 100.0
chr17 5486901 5486905 51 frequency-based,homology-based asisi 3/3 19 15 17 0 MIS12 4 23 28 1.22 100.0
chr2 85595471 85595475 47 frequency-based,homology-based asisi 3/3 18 16 13 0 ENSG00000288858 4 22 25 1.14 100.0
chr21 31873202 31873210 47 frequency-based,homology-based asisi 3/3 13 16 18 0 HUNK (CGG)n 8 17 30 1.76 100.0
chr9 36258515 36258521 46 frequency-based,homology-based asisi 3/3 16 22 8 0 CLTA,GNE 6 19 27 1.42 100.0
chr11 24496930 24496934 46 frequency-based,homology-based asisi 3/3 17 12 17 0 LUZP2 4 21 25 1.19 100.0
chr4 83013134 83013138 45 frequency-based,homology-based asisi 3/3 19 17 9 0 4 28 17 1.65 100.0
chr20 38731626 38731630 45 frequency-based,homology-based asisi 3/3 16 14 15 0 4 30 15 2.00 100.0
chr5 69167024 69167028 44 frequency-based,homology-based asisi 3/3 17 12 15 0 4 24 20 1.20 100.0
chr6 37354036 37354040 42 frequency-based,homology-based asisi 3/3 18 8 16 0 RNF8 4 17 25 1.47 100.0
chrX 73563267 73563271 42 frequency-based,homology-based asisi 3/3 9 14 19 0 CHIC1 4 17 25 1.47 100.0
chr3 52198147 52198154 40 frequency-based,homology-based asisi 3/3 10 9 21 0 ALAS1 7 25 15 1.67 100.0
chr6 135498210 135498214 39 frequency-based,homology-based asisi 3/3 12 13 14 0 AHI1,AHI1-DT 4 19 20 1.05 100.0
chr8 115668405 115668412 37 frequency-based,homology-based asisi 3/3 13 14 10 0 TRPS1 (T)n,(CGCGCCC)n 7 23 14 1.64 100.0
chr21 44801875 44801879 37 frequency-based,homology-based asisi 3/3 8 19 10 0 UBE2G2,LINC01424 4 19 18 1.06 100.0
chr2 74507635 74507639 36 frequency-based,homology-based asisi 3/3 5 13 18 0 PCGF1 4 26 10 2.60 100.0
chr19 29528579 29528585 36 frequency-based,homology-based asisi 3/3 9 13 14 0 VSTM2B 6 14 22 1.57 100.0
chrX 45507149 45507153 36 frequency-based,homology-based asisi 3/3 10 13 13 0 LINC01204 4 27 9 3.00 100.0
chr13 114129184 114129188 34 frequency-based,homology-based asisi 3/3 7 12 15 0 RASA3 4 17 17 1.00 100.0
chr19 2456096 2456100 34 frequency-based,homology-based asisi 3/3 6 15 13 0 LMNB2 4 22 12 1.83 100.0
chr6 66994128 66994132 32 frequency-based,homology-based asisi 3/3 9 12 11 0 AluSc 4 20 12 1.67 100.0
chr7 76178189 76178193 31 frequency-based,homology-based asisi 3/3 10 9 12 0 4 18 13 1.38 100.0
chrX 53082245 53082249 30 frequency-based,homology-based asisi 3/3 7 7 16 0 4 15 15 1.00 100.0
chr14 52695639 52695643 29 frequency-based,homology-based asisi 3/3 10 12 7 0 ERO1A 4 19 10 1.90 100.0
chr4 177442422 177442426 28 frequency-based,homology-based asisi 3/3 6 7 15 0 AGA 4 18 10 1.80 100.0
chr20 20052281 20052285 28 frequency-based,homology-based asisi 3/3 9 9 10 0 CRNKL1 4 15 13 1.15 100.0
chr22 20496021 20496025 28 frequency-based,homology-based asisi 3/3 12 7 9 0 MED15 4 19 9 2.11 100.0
chr2 5697064 5697068 27 frequency-based,homology-based asisi 3/3 8 8 11 0 SOX11,ENSG00000242540 4 9 18 2.00 100.0
chr2 43131200 43131204 27 frequency-based,homology-based asisi 3/3 3 16 8 0 LINC02580,ENSG00000286796 4 23 4 5.75 100.0
chr11 85664611 85664615 26 frequency-based,homology-based asisi 3/3 8 9 9 0 CREBZF 4 17 9 1.89 100.0
chr19 41397838 41397842 26 frequency-based,homology-based asisi 3/3 7 10 9 0 ENSG00000255730,BCKDHA 4 17 9 1.89 100.0
chr8 65634113 65634117 25 frequency-based,homology-based asisi 3/3 6 9 10 0 ARMC1 4 13 12 1.08 100.0
chr2 55281965 55281969 24 frequency-based,homology-based asisi 3/3 11 5 8 0 AluSx1 4 15 9 1.67 100.0
chr7 93232178 93232182 24 frequency-based,homology-based asisi 3/3 7 7 10 0 4 10 14 1.40 100.0
chr11 75814716 75814720 24 frequency-based,homology-based asisi 3/3 7 9 8 0 UVRAG-DT 4 17 7 2.43 100.0
chr9 134326231 134326235 23 frequency-based,homology-based asisi 3/3 7 2 14 0 RXRA 4 7 16 2.29 100.0
chr19 41993704 41993708 23 frequency-based,homology-based asisi 3/3 11 6 6 0 ENSG00000285505,ATP1A3 4 19 4 4.75 100.0
chr20 33444281 33444285 22 frequency-based,homology-based asisi 3/3 7 9 6 0 AluJb 4 8 14 1.75 100.0
chr6 149566970 149566974 21 frequency-based,homology-based asisi 3/3 7 7 7 0 GINM1 4 10 11 1.10 100.0
chr7 100081885 100081889 21 frequency-based,homology-based asisi 3/3 9 5 7 0 ZNF3 4 10 11 1.10 100.0
chr13 104586201 104586205 21 frequency-based,homology-based asisi 3/3 6 9 6 0 4 9 12 1.33 100.0
chr5 80488321 80488325 20 frequency-based,homology-based asisi 3/3 4 7 9 0 FAM151B 4 13 7 1.86 100.0
chr6 144286433 144286437 20 frequency-based,homology-based asisi 3/3 9 6 5 0 UTRN 4 13 7 1.86 100.0
chr17 39981220 39981224 20 frequency-based,homology-based asisi 3/3 11 3 6 0 PSMD3 4 9 11 1.22 100.0
chr1 9589388 9589392 19 frequency-based,homology-based asisi 3/3 9 5 5 0 TMEM201 4 9 10 1.11 100.0
chr9 29212802 29212808 19 frequency-based,homology-based asisi 3/3 8 3 8 0 LINGO2 6 8 11 1.38 100.0
chr12 121537153 121537157 19 frequency-based,homology-based asisi 3/3 7 7 5 0 KDM2B 4 11 8 1.38 100.0
chr17 44363567 44363571 19 frequency-based,homology-based asisi 3/3 8 7 4 0 FAM171A2 4 8 11 1.38 100.0
chr20 1226972 1226976 18 frequency-based,homology-based asisi 3/3 4 9 5 0 RAD21L1 AluSx1 4 9 9 1.00 100.0
chr1 109984953 109984957 17 frequency-based,homology-based asisi 3/3 4 4 9 0 AHCYL1 4 10 7 1.43 100.0
chr2 207166004 207166005 17 frequency-based,homology-based asisi 3/3 4 5 8 0 KLF7 (C)n 1 0 17 100.0
chr6 49949873 49949874 17 frequency-based,homology-based asisi 3/3 7 5 5 0 ENSG00000290804 AluY 1 17 0 100.0
chr9 124769827 124769831 17 frequency-based,homology-based asisi 3/3 8 4 5 0 NR6A1 4 8 9 1.12 100.0
chr19 2456598 2456602 17 frequency-based,homology-based asisi 3/3 6 5 6 0 LMNB2 4 9 8 1.12 100.0
chr1 228140380 228140384 16 frequency-based,homology-based asisi 3/3 5 4 7 0 GUK1 4 8 8 1.00 100.0
chr3 98899324 98899325 16 frequency-based,homology-based asisi 3/3 5 6 5 0 DCBLD2 AluSc8 1 16 0 100.0
chr1 204411325 204411329 15 frequency-based,homology-based asisi 3/3 3 6 6 0 PPP1R15B-AS1,PPP1R15B,ENSG00000288934 4 8 7 1.14 100.0
chr3 196868111 196868115 15 frequency-based,homology-based asisi 3/3 3 5 7 0 SENP5 4 10 5 2.00 100.0
chrX 48957422 48957426 15 frequency-based,homology-based asisi 3/3 2 4 9 0 OTUD5 (CGC)n 4 5 10 2.00 100.0
chrX 150693993 150693997 15 frequency-based,homology-based asisi 3/3 4 6 5 0 MTMR1 4 4 11 2.75 100.0
chr5 180292535 180292539 14 frequency-based,homology-based asisi 3/3 4 4 6 0 ENSG00000248367 4 6 8 1.33 100.0
chr12 129607336 129607340 14 frequency-based,homology-based asisi 3/3 4 7 3 0 TMEM132D MER77 4 5 9 1.80 100.0
chr14 54489107 54489109 14 frequency-based,homology-based asisi 3/3 3 6 5 0 (T)n 2 0 14 100.0
chr15 58933091 58933095 14 frequency-based,homology-based asisi 3/3 5 6 3 0 RNF111,SLTM 4 11 3 3.67 100.0
chr18 32018760 32018764 14 frequency-based,homology-based asisi 3/3 7 3 4 0 4 7 7 1.00 100.0
chr1 230868488 230868489 13 frequency-based,homology-based asisi 3/3 4 4 5 0 C1orf198,ENSG00000223393 1 0 13 100.0
chr8 31640323 31640327 13 frequency-based,homology-based asisi 3/3 5 4 4 0 NRG1 (GCG)n,(GCCGCGA)n 4 9 4 2.25 100.0
chr9 128127129 128127133 13 frequency-based,homology-based asisi 3/3 5 5 3 0 PTGES2 AluJb 4 6 7 1.17 100.0
chr10 92291258 92291262 13 frequency-based,homology-based asisi 3/3 4 6 3 0 MARCHF5 4 3 10 3.33 100.0
chr2 70767416 70767420 12 frequency-based,homology-based asisi 3/3 4 6 2 0 ADD2 (CGCCC)n 4 5 7 1.40 100.0
chr4 2058959 2058963 12 frequency-based,homology-based asisi 3/3 5 4 3 0 G-rich 4 4 8 2.00 100.0
chr6 20212090 20212094 12 frequency-based,homology-based asisi 3/3 2 3 7 0 MBOAT1,ENSG00000227803 4 9 3 3.00 100.0
chr8 22565959 22565963 12 frequency-based,homology-based asisi 3/3 4 6 2 0 SORBS3,ENSG00000254230 4 7 5 1.40 100.0
chr8 123768970 123768974 12 frequency-based,homology-based asisi 3/3 2 6 4 0 FAM91A1 4 7 5 1.40 100.0
chr9 109780072 109780076 12 frequency-based,homology-based asisi 3/3 1 4 7 0 PALM2AKAP2 4 5 7 1.40 100.0
chr11 100687581 100687585 12 frequency-based,homology-based asisi 3/3 4 2 6 0 ARHGAP42-AS1,ARHGAP42 4 6 6 1.00 100.0
chr17 4366229 4366233 12 frequency-based,homology-based asisi 3/3 7 1 4 0 UBE2G1 4 9 3 3.00 100.0
chr17 82273235 82273240 12 frequency-based,homology-based asisi 3/3 4 5 3 0 CSNK1D 5 6 6 1.00 100.0
chr19 38336687 38336691 12 frequency-based,homology-based asisi 3/3 4 1 7 0 CATSPERG 4 8 4 2.00 100.0

Breaksite Plots

Mismatch Plots

asisi_treated asisi

srfi_noti_treated

Nominations

Chr Start End Count Rationale Guide name Reproducibility Count (noti and srfi digested rep1) Count (noti and srfi digested rep2) Count (noti and srfi digested rep3) Noti mismatches Srfi mismatches Intersect with genes Intersect with repeat mask Width Plus count Minus count Count ratio Percent id to noti Percent id to srfi
chr2 69914897 69914902 1247 frequency-based,homology-based srfi 3/3 389 401 457 0 MXD1 5 641 606 1.06 62.5 100.0
chr19 55605463 55605466 1183 frequency-based,homology-based srfi 3/3 352 371 460 0 3 707 476 1.49 75.0 100.0
chr5 73565405 73565408 1061 frequency-based,homology-based srfi 3/3 328 352 381 0 ANKRA2,UTP15 3 646 415 1.56 75.0 100.0
chr17 44186688 44186690 1059 frequency-based,homology-based srfi 3/3 339 347 373 0 ASB16-AS1 2 627 432 1.45 75.0 100.0
chr2 85354575 85354584 1057 frequency-based,homology-based srfi 3/3 303 353 401 0 RETSAT,ELMOD3 9 720 337 2.14 62.5 100.0
chr9 137255162 137255164 1049 frequency-based,homology-based srfi 3/3 299 367 383 0 2 419 630 1.50 75.0 100.0
chr12 104958386 104958394 1024 frequency-based,homology-based srfi 3/3 301 340 383 0 SLC41A2 8 437 587 1.34 87.5 100.0
chr19 1249740 1249745 1017 frequency-based,homology-based srfi 3/3 291 322 404 0 MIDN 5 611 406 1.50 87.5 100.0
chr11 73761105 73761110 1012 frequency-based,homology-based srfi 3/3 288 333 391 0 RAB6A,ENSG00000256034 (GCGT)n 5 463 549 1.19 87.5 100.0
chr12 56688316 56688319 995 frequency-based,homology-based srfi 3/3 311 320 364 0 PTGES3 3 492 503 1.02 87.5 100.0
chr9 132355122 132355137 986 frequency-based,homology-based noti 3/3 286 329 371 0 15 430 556 1.29 100.0 75.0
chr11 66313007 66313010 981 frequency-based,homology-based srfi 3/3 293 321 367 0 ENSG00000289560,ENSG00000254458 3 454 527 1.16 62.5 100.0
chr2 218568464 218568468 970 frequency-based,homology-based srfi 3/3 295 308 367 0 (CCGCC)n 4 381 589 1.55 75.0 100.0
chr11 102347262 102347266 967 frequency-based,homology-based srfi 3/3 320 318 329 0 BIRC2 4 530 437 1.21 75.0 100.0
chr9 128068133 128068137 964 frequency-based,homology-based srfi 3/3 296 308 360 0 NAIF1 G-rich 4 392 572 1.46 75.0 100.0
chr17 1456388 1456398 949 frequency-based,homology-based srfi 3/3 294 328 327 0 CRK 10 472 477 1.01 75.0 100.0
chr17 1516834 1516842 946 frequency-based,homology-based noti 3/3 268 340 338 0 PITPNA-AS1 8 382 564 1.48 100.0 87.5
chr21 39312558 39312576 946 frequency-based,homology-based noti 3/3 300 299 347 0 BRWD1 (GCCCC)n 18 537 409 1.31 100.0 62.5
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr17 81488002 81488018 937 homology-based noti,srfi 3/3 296 299 342 0 0 16 484 453 1.07 100.0 100.0
chr20 33686632 33686635 916 homology-based srfi 3/3 256 313 347 0 (GCGGC)n 3 425 491 1.16 75.0 100.0
chr7 157010830 157010832 915 homology-based srfi 3/3 318 315 282 0 MNX1-AS1 (CCGCC)n 2 403 512 1.27 62.5 100.0
chr7 138460126 138460138 913 homology-based noti 3/3 281 301 331 0 G-rich 12 462 451 1.02 100.0 75.0
chr12 117190503 117190505 912 homology-based srfi 3/3 265 302 345 0 FBXO21 (CCG)n,(CG)n 2 450 462 1.03 75.0 100.0
chr2 223957283 223957299 910 homology-based noti 3/3 291 276 343 0 16 448 462 1.03 100.0 75.0
chr14 20682832 20682834 909 homology-based srfi 3/3 296 283 330 0 2 381 528 1.39 62.5 100.0
chr11 85628508 85628510 893 homology-based srfi 3/3 288 297 308 0 2 419 474 1.13 75.0 100.0
chr11 72793728 72793739 879 homology-based noti 3/3 276 250 353 0 STARD10,ENSG00000285693 11 462 417 1.11 100.0 75.0
chr15 64163292 64163294 879 homology-based srfi 3/3 286 294 299 0 2 409 470 1.15 87.5 100.0
chr1 62436278 62436280 878 homology-based srfi 3/3 272 304 302 0 USP1 2 502 376 1.34 75.0 100.0
chr10 31760154 31760160 878 homology-based srfi 3/3 284 262 332 0 ENSG00000289412 6 486 392 1.24 62.5 100.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr11 65919098 65919117 868 homology-based noti 3/3 247 286 335 0 C11orf68 G-rich 19 486 382 1.27 100.0 75.0
chr7 76318194 76318208 853 homology-based noti 3/3 258 249 346 0 FPASL 14 387 466 1.20 100.0 75.0
chr17 31549959 31549963 848 homology-based srfi 3/3 282 247 319 0 (CGGGGC)n 4 310 538 1.74 75.0 100.0
chr15 65611261 65611263 847 homology-based srfi 3/3 257 284 306 0 INTS14 2 467 380 1.23 62.5 100.0
chr3 12484434 12484442 843 homology-based noti 3/3 267 271 305 0 TSEN2 8 464 379 1.22 100.0 62.5
chr10 97687418 97687420 838 homology-based srfi 3/3 247 267 324 0 2 414 424 1.02 75.0 100.0
chr16 70381403 70381416 836 homology-based noti 3/3 244 276 316 0 ST3GAL2,ENSG00000260111 13 365 471 1.29 100.0 75.0
chr19 45717433 45717445 835 homology-based noti 3/3 270 269 296 0 FBXO46 12 390 445 1.14 100.0 75.0

Breaksite Plots

Mismatch Plots

srfi_noti_treated noti

srfi_noti_treated srfi

Workflow Warnings and Errors

Note

No errors found

QC Plots

gDNA yield (ng) per sample

gDNA yield (ng) per condition

Library yield (ng) per sample

Library yield (ng) per condition

gDNA yield (ng) vs library yield (ng)

qPCR conc (pM) per sample

qPCR conc (pM) per condition

Break QC Plots

Absolute number of breaks per sample

Absolute number of breaks per condition

Normalised breaks (by ng of gDNA) per sample

Normalised breaks (by ng of gDNA) per condition

qPCR conc (pM) vs absolute number of breaks